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研究論文

ラボ実験

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1. 肛門の非上皮性腫瘍の診断と治療

藤吉健司,  藤田文彦, 大地貴史, 合志健一, 吉田武史, 溝部智亮, 村上直孝, 赤木由人, 消化器・肝臓内科, 8(6):1-7, 2020.

 

2. Pagetoid spreadを伴う肛門腺由来肛門管癌の1例

藤吉 健司, 日高 敦弘, 主藤 朝也, 白土 一太郎, 田中 裕穂, 草野 弘宣, 赤木 由人, 日本臨床外科学会雑誌, 2015, 76 巻, 5号,  p1118-1123, 公開日2015/11/30, Online ISSN 1882-5133, Print ISSN 1345-2843

 

3. 十二指腸上行脚に発生した腸症型T細胞性リンパ腫の1例

藤吉 健司, 末吉 普, 津福 達二, 堀尾 卓矢, 衛藤 大明, 今井 伸一, 赤木 由人, 白水 和雄, 島松 一秀, 日本消化器外科学会雑誌, 2014, 47巻,10号,p580-587, 公開日 2014/10/10, Online ISSN 1348-9372, Print ISSN 0386-9768,

4. 大腸の体腔内吻合を行うかどうか:体腔内吻合を行うvs体腔内吻合を行わない。

藤田文彦, 緒方傑, 中根浩幸, 藤吉健司, 大地貴史, 合志健一, 吉田武史, 溝部智亮, 赤木由人, 消化器外科2020-12

5. Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study

Fujiyoshi K, Sudo T, Fujita F, Chino A, Akagi K, Takao A, Yamada M, Tanakaya K, Ishida H, Komori K, Ishihara S, Miguchi M, Hirata K, Miyakura Y, Ishikawa T, Yamaguchi T, Tomita N, Ajioka Y, Sugihara K.
Int J Clin Oncol. 2022 Mar 23. doi: 10.1007/s10147-022-02148-2.

 

6. Opinion: Standardizing gene product nomenclature-a call to action.

Fujiyoshi K, Bruford EA, Mroz P, Sims CL, O'Leary TJ, Lo AWI, Chen N, Patel NR, Patel KP, Seliger B, Song M, Monzon FA, Carter AB, Gulley ML, Mockus SM, Phung TL, Feilotter H, Williams HE, Ogino S. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2025207118.

7. Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction.

Fujiyoshi K, Chen Y, Haruki K, Ugai T, Kishikawa J, Hamada T, Liu L, Arima K, Borowsky J, Väyrynen JP, Zhao M, Lau MC, Gu S, Shi S, Akimoto N, Twombly TS, Drew DA, Song M, Chan AT, Giovannucci EL, Meyerhardt JA, Fuchs CS, Nishihara R, Lennerz JK, Giannakis M, Nowak JA, Zhang X, Wu K, Ogino S. JNCI Cancer Spectr. 2020 May 14;4(5):pkaa040.

8. Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer.

Fujiyoshi K, Väyrynen JP, Borowsky J, Papke DJ Jr, Arima K, Haruki K, Kishikawa J, Akimoto N, Ugai T, Lau MC, Gu S, Shi S, Zhao M, Da Silva AFL, Twombly TS, Nan H, Meyerhardt JA, Song M, Zhang X, Wu K, Chan AT, Fuchs CS, Lennerz JK, Giannakis M, Nowak JA, Ogino S. EBioMedicine. 2020 Jul;57:102860. 

9. Metastatic Pattern of Stage IV Colorectal Cancer with High-Frequency Microsatellite Instability as a Prognostic Factor. 

Fujiyoshi K, Yamamoto G, Takenoya T, Takahashi A, Arai Y, Yamada M, Kakuta M, Yamaguchi K, Akagi Y, Nishimura Y, Sakamoto H, Akagi K. Anticancer Res. 2017 Jan;37(1):239-247.

10. High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases.

Fujiyoshi K, Yamamoto G, Takahashi A, Arai Y, Yamada M, Kakuta M, Yamaguchi K, Akagi Y, Nishimura Y, Sakamoto H, Akagi K. Oncol Rep. 2017 Feb;37(2):785-792. 

11. ​Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age. 

Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K. Cancer Med. 2017 Jun;6(6):1255-1263. 

12. Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer.

Arima K, Lau MC, Zhao M, Haruki K, Kosumi K, Mima K, Gu M, Väyrynen JP, Twombly TS, Baba Y, Fujiyoshi K, Kishikawa J, Guo C, Baba H, Richards WG, Chan AT, Nishihara R, Meyerhardt JA, Nowak JA, Giannakis M, Fuchs CS, Ogino S. Mol Cancer Res. 2020 Jun;18(6):883-890.

13. Risk Prediction Model Based on Prognostic Factors Beyond Lymph Node Status in Colorectal Cancer Stages II/III: An Integration of Mixed Clinicopathologic Data Using Bayesian Ensemble Trees.

Melissa Zhao, Mai Chan Lau, Koichiro Haruki, Juha Vayrynen, Sara Vayrynen, Andressa Dias Costa, Jennifer Borowsky, Simeng Gu, Carino Gurjao, Kenji Fujiyoshi, Kota Arima, Tsuyoshi Hamada, Jochen Lennerz, Charles Fuchs, Andrew Chan, Kimmie Ng, Kana Wu, Xuehong Zhang, Jeffrey Meyerhardt, Mingyang Song, Jonathan Nowak, Marios Giannakis, Nishihara Reiko, Shuji Ogino. LABORATORY INVESTIGATION 100 (SUPPL 1), 814-814

14. MSI AND IMMUNOSCORE COMBINED UTILIZATION FOR THE EVALUATION OF ANTI-TUMOR IMMUNITY IN CRC.

Sudo T, Nakane H, Shigaki T, Fujiyoshi K, Ogata S, Ochi T, Mizobe T, Fujita F, Kinugasa T, Akiba J, Akagi Y. DISEASES OF THE COLON & RECTUM 63 (6), E216-E216

15. The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment.

Väyrynen JP, Haruki K, Lau MC, Väyrynen SA, Zhong R, Dias Costa A, Borowsky J, Zhao M, Fujiyoshi K, Arima K, Twombly TS, Kishikawa J, Gu S, Aminmozaffari S, Shi S, Baba Y, Akimoto N, Ugai T, Da Silva A, Guerriero JL, Song M, Wu K, Chan AT, Nishihara R, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S, Nowak JA. Cancer Immunol Res. 2021 Jan;9(1):8-19.

16. Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response.

Ugai T, Haruki K, Väyrynen JP, Zhong R, Borowsky J, Fujiyoshi K, Lau MC, Zhao M, Akimoto N, Chang TW, Kishikawa J, Arima K, Shi SS, Gu S, Fuchs CS, Giovannucci EL, Giannakis M, Zhang X, Song M, Meyerhardt JA, Wang M, Nowak JA, Ogino S. JNCI Cancer Spectr. 2020 Sep 7;4(6):pkaa068.

17. Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report.

Watanabe M, Yamamoto G, Fujiyoshi K, Akagi Y, Kakuta M, Nishimura Y, Akagi K.

J Med Case Rep. 2019 Apr 27;13(1):117.

18. Rising incidence of early-onset colorectal cancer—a call to action.

Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S. Nat Rev Clin Oncol. 2020 Nov 20.

19. Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes.

Wang L, He X, Ugai T, Haruki K, Lo CH, Hang D, Akimoto N, Fujiyoshi K, Wang M, Fuchs CS, Meyerhardt JA, Zhang X, Wu K, Chan AT, Giovannucci EL, Ogino S, Song M. JNCI Cancer Spectr. 2020 Oct 7;5(1):pkaa089.

20. Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections.

Väyrynen JP, Lau MC, Haruki K, Väyrynen SA, Dias Costa A, Borowsky J, Zhao M, Fujiyoshi K, Arima K, Twombly TS, Kishikawa J, Gu S, Aminmozaffari S, Shi S, Baba Y, Akimoto N, Ugai T, Da Silva A, Song M, Wu K, Chan AT, Nishihara R, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S, Nowak JA. Clin Cancer Res. 2020 Aug 15;26(16):4326-4338.

21. Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer.

Arima K, Lau MC, Zhao M, Haruki K, Kosumi K, Mima K, Gu M, Väyrynen JP, Twombly TS, Baba Y, Fujiyoshi K, Kishikawa J, Guo C, Baba H, Richards WG, Chan AT, Nishihara R, Meyerhardt JA, Nowak JA, Giannakis M, Fuchs CS, Ogino S. Mol Cancer Res. 2020 Jun;18(6):883-890.

22. An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer.

Haruki K, Kosumi K, Li P, Arima K, Väyrynen JP, Lau MC, Twombly TS, Hamada T, Glickman JN, Fujiyoshi K, Chen Y, Du C, Guo C, Väyrynen SA, Dias Costa A, Song M, Chan AT, Meyerhardt JA, Nishihara R, Fuchs CS, Liu L, Zhang X, Wu K, Giannakis M, Nowak JA, Ogino S. Br JCancer. 2020 Apr;122(9):1367-1377.

23. Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer.

Haruki K, Kosumi K, Hamada T, Twombly TS, Väyrynen JP, Kim SA, Masugi Y, Qian ZR, Mima K, Baba Y, da Silva A, Borowsky J, Arima K, Fujiyoshi K, Lau MC, Li P, Guo C, Chen Y, Song M, Nowak JA, Nishihara R, Yanaga K, Zhang X, Wu K, Bullman S, Garrett WS, Huttenhower C, Meyerhardt JA, Giannakis M, Chan AT, Fuchs CS, Ogino S. J Pathol. 2020 Apr;250(4):397-408.

24. Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer.

Nagasu S, Sudo T, Kinugasa T, Yomoda T, Fujiyoshi K, Shigaki T, Akagi Y. Oncol Rep. 2019 May;41(5):2889-2896.

25. Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing.

Yamamoto G, Kikuchi M, Kobayashi S, Arai Y, Fujiyoshi K, Watatsuki T, Kakuta M, Yamane Y, Iijima Y, Mizutani H, Nakajima Y, Sudo J, KInshita H, Kurimoto F, Akiyama H, Uramoto H, Sakai H, Akagi Y, Akagi K. Int J Oncol. 2017 May;50(5):1579-1589. 

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